Stents versus coronary-artery bypass grafting for left main coronary artery disease.

نویسندگان

  • Ki Bae Seung
  • Duk-Woo Park
  • Young-Hak Kim
  • Seung-Whan Lee
  • Cheol Whan Lee
  • Myeong-Ki Hong
  • Seong-Wook Park
  • Sung-Cheol Yun
  • Hyeon-Cheol Gwon
  • Myung-Ho Jeong
  • Yangsoo Jang
  • Hyo-Soo Kim
  • Pum Joon Kim
  • In-Whan Seong
  • Hun Sik Park
  • Taehoon Ahn
  • In-Ho Chae
  • Seung-Jea Tahk
  • Wook-Sung Chung
  • Seung-Jung Park
چکیده

BACKGROUND Several studies have compared the treatment effects of coronary stenting and coronary-artery bypass grafting (CABG). However, there are limited data regarding the long-term outcomes of these two interventions for patients with unprotected left main coronary artery disease. METHODS We evaluated 1102 patients with unprotected left main coronary artery disease who underwent stent implantation and 1138 patients who underwent CABG in Korea between January 2000 and June 2006. We compared adverse outcomes (death; a composite outcome of death, Q-wave myocardial infarction, or stroke; and target-vessel revascularization) with the use of propensity-score matching in the overall cohort and in separate subgroups according to type of stent. RESULTS In the overall matched cohort, there was no significant difference between the stenting and CABG groups in the risk of death (hazard ratio for the stenting group, 1.18; 95% confidence interval [CI], 0.77 to 1.80) or the risk of the composite outcome (hazard ratio for the stenting group, 1.10; 95% CI, 0.75 to 1.62). The rates of target-vessel revascularization were significantly higher in the group that received stents than in the group that underwent CABG (hazard ratio, 4.76; 95% CI, 2.80 to 8.11). Comparisons of the group that received bare-metal stents with the group that underwent CABG and of the group that received drug-eluting stents with the group that underwent CABG produced similar results, although there was a trend toward higher rates of death and the composite end point in the group that received drug-eluting stents. CONCLUSIONS In a cohort of patients with unprotected left main coronary artery disease, we found no significant difference in rates of death or of the composite end point of death, Q-wave myocardial infarction, or stroke between patients receiving stents and those undergoing CABG. However, stenting, even with drug-eluting stents, was associated with higher rates of target-vessel revascularization than was CABG.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Outcomes of coronary artery bypass grafting versus percutaneous coronary intervention with second-generation drug-eluting stents for patients with multivessel and unprotected left main coronary artery disease

OBJECTIVES To compare the efficacy and safety of percutaneous coronary intervention using second-generation drug-eluting stents with those of coronary artery bypass grafting among patients with multivessel disease and/or unprotected left main coronary artery disease in terms of mortality, myocardial infarction, repeat revascularization, and angina. BACKGROUND Although coronary artery disease ...

متن کامل

Stent area by intravascular ultrasound and outcomes in left main intervention with drug-eluting stents: small stents, more events.

While the standard revascularization for left main lesions traditionally has been surgical coronary artery bypass grafting, increasingly studies suggest that percutaneous coronary intervention (PCI) with drug-eluting stents (DES) may be an acceptable alternative to surgery for selected patients. In total, the current evidence suggests that rates of death, myocardial infarction, and stroke may b...

متن کامل

No More Debate Over Left Main Stenting Versus Bypass Surgery.

SEE PAGE 318 T raditionally, left main coronary artery disease had been regarded as a dominion of the cardiac surgeons on the basis of results from the classic trial comparing medical treatment and bypass surgery (1,2). However, several brave pioneers in interventional cardiology have continued to evaluate the performance of “less invasive” coronary stenting for the left main coronary artery st...

متن کامل

Coronary artery bypass grafting following in-stent restenosis of drug-eluting stents deployed in the left main coronary artery.

Two cases of drug-eluting stent restenosis after percutaneous coronary intervention in the left main coronary artery and its bifurcation are presented. An off-pump coronary artery bypass grafting following in-stent restenosis was performed. Drug-eluting stents have shown a reduced frequency of in-stent restenosis and a good safety profile compared with bare metal stents. However, intervention w...

متن کامل

Cardiac Myxoma Removal and Coronary Artery Bypass Grafting in a Middle-Aged Woman: A Case Report

Cardiac myxoma is usually a benign tumor in the left atrium that accounts for more than 50% of primary cardiac tumors. A 55-year-old female referred to our hospital with chest pain, referred pain to the left hand, and severe dyspnea. Transthoracic Doppler Echocardiography was performed and the results showed a large and mobile left atrial mass without any attachment to the interatrial septum. I...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • The New England journal of medicine

دوره 358 17  شماره 

صفحات  -

تاریخ انتشار 2008